A proliferation‐inducing ligand–mediated anti‐inflammatory response of astrocytes in multiple sclerosis
نویسندگان
چکیده
منابع مشابه
The Role of Astrocytes in Multiple Sclerosis
The role traditionally assigned to astrocytes in the pathogenesis of multiple sclerosis (MS) lesions has been the formation of the glial scar once inflammation has subsided. Astrocytes are now recognized to be early and highly active players during lesion formation and key for providing peripheral immune cells access to the central nervous system. Here, we review the role of astrocytes in the f...
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Multiple sclerosis (MS) is an inflammatory disorder causing central nervous system (CNS) demyelination and axonal injury. Although its etiology remains elusive, several lines of evidence support the concept that autoimmunity plays a major role in disease pathogenesis. The course of MS is highly variable; nevertheless, the majority of patients initially present a relapsing-remitting clinical cou...
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Multiple sclerosis (MS) is an immune-mediated disease of the central nervous system (CNS). This highlydisabling disorder is characterized by a variable clinical course. MS is a heterogeneous disease with acomplex pathology and significant social and economic impact. MS is associated with dysfunction ofparts of the nervous system which results in a range of signs and symptoms, ...
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Multiple sclerosis is an autoimmune disease of the central nervous system which its main characteristic is an inflammation and demyelination and subsequent, neural degeneration. Many studies have shown that inflammation causing neuronal demyelination. MS is the most common cause of chronic neurological disability in during youth which the prognosis is that can be death. Platelet activating fact...
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Summary The immunosuppressive agent has changed the clinical course of MS. Mostly,this agent, like cyclophosphamide cyclosporine A., and X-Ray of the lymphoid organ, has a lot of side effects. It should only be used in the most severe from of MS among immunosuppressive agents, Azathioprin has been used most frequently in spite of the fact that it is not very effective compared with other immun...
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ژورنال
عنوان ژورنال: Annals of Neurology
سال: 2019
ISSN: 0364-5134,1531-8249
DOI: 10.1002/ana.25415